TCU junior guard Natasha Lacy recorded her third double-double of the season with 15 points and 17 rebounds.
Lacy's 17 rebounds surpassed her previous career-high of 14 against Marquette on Feb. 20, 2004.
TCU sophomore guard Adrianne Ross's 21 points was a single-game team high this season. It was the third time in her career she has scored 20 or more in a game and the 14th time she has reached double figures in the scoring column.
TCU junior forward Ashley Davis hit her 100th career three-pointer, becoming just the sixth Lady Frog to reach the century mark.
TCU sophomore forward Jenna Lohse scored six points to set a new career-high.
After committing 16 turnovers in the first half, TCU had only seven in the second.
TCU led 20-15 in the first half with just over 11 minutes to go before USC scored 13 unanswered and outscored the Lady Frogs 24-10 the remainder of the period.
Second chance points favored USC 23-12, while TCU outscored USC 16-6 in the paint.
TCU's 2-4 record through six games is the worst since it started 1-5 for the 1995-96 season.